Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals
Identifieur interne : 000015 ( 1968/Analysis ); précédent : 000014; suivant : 000016Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals
Auteurs : Yulia Desheva [Russie] ; Ivan Sychev [Russie] ; Tatiana Smolonogina [Russie] ; Andrey Rekstin [Russie] ; Natalia Ilyushina [États-Unis] ; Vladimir Lugovtsev [États-Unis] ; Anastasia Samsonova [États-Unis] ; Aleksey Go [Russie] ; Anna Lerner [Russie]Source :
- PLoS ONE [ 1932-6203 ] ; 2018.
Abstract
The main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies against A/H1N1pdm09 influenza viruses in the community as a whole and after infection. We evaluated NI serum antibodies against A/California/07/09(H1N1)pdm and A/South Africa/3626/2013(H1N1)pdm in 134 blood donors of different ages using enzyme-linked lectin assay and in 15 paired sera from convalescents with laboratory confirmed influenza. The neuraminidase (NA) proteins of both A/H1N1pdm09 viruses had minimal genetic divergence, but demonstrated different enzymatic and antigenic properties. 5.2% of individuals had NI antibody titers ≥1:20 against A/South Africa/3626/2013(H1N1)pdm compared to 53% of those who were positive to A/California/07/2009(H1N1)pdm NA. 2% of individuals had detectable NI titers against A/South Africa/3626/13(H1N1)pdm and 47.3% were positive to A/California/07/2009(H1N1)pdm NA among participants negative to hemagglutinin (HA) of A/H1N1pdm09 but positive to seasonal A/H1N1. The lowest NI antibody levels to both A/H1N1pdm09 viruses were detected in individuals born between 1956 and 1968. Our data suggest that NI antibodies against A/South Africa/3626/13 (H1N1)pdm found in the blood donors could have resulted from direct infection with a new antigenic A/H1N1pdm09 variant rather than from cross-reaction as a result of contact with previously circulating seasonal A/H1N1 variants. The immune responses against HA and NA were formed simultaneously right after natural infection with A/H1N1pdm09. NI antibodies correlated with virus-neutralizing antibodies when acquired shortly after influenza infection. A group of middle-aged patients with the lowest level of anti-NA antibodies against A/California/07/2009 (H1N1)pdm was identified, indicating the highest-priority vaccination against A/H1N1pdm09 viruses.
Url:
DOI: 10.1371/journal.pone.0196771
PubMed: 29742168
PubMed Central: 5942809
Affiliations:
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PMC:5942809Le document en format XML
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wicri:level="1"><nlm:aff id="aff001"><addr-line>Virology Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Virology Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Fundamental Problems of Medicine and Medical Technologies, Saint Petersburg State University, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Fundamental Problems of Medicine and Medical Technologies, Saint Petersburg State University, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Sychev, Ivan" sort="Sychev, Ivan" uniqKey="Sychev I" first="Ivan" last="Sychev">Ivan Sychev</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Virology Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Virology Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Smolonogina, Tatiana" sort="Smolonogina, Tatiana" uniqKey="Smolonogina T" first="Tatiana" last="Smolonogina">Tatiana Smolonogina</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Virology Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country 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last="Ilyushina">Natalia Ilyushina</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lugovtsev, Vladimir" sort="Lugovtsev, Vladimir" uniqKey="Lugovtsev V" first="Vladimir" last="Lugovtsev">Vladimir Lugovtsev</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Samsonova, Anastasia" sort="Samsonova, Anastasia" uniqKey="Samsonova A" first="Anastasia" last="Samsonova">Anastasia Samsonova</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Go, Aleksey" sort="Go, Aleksey" uniqKey="Go A" first="Aleksey" last="Go">Aleksey Go</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Clinical and Diagnostic Center, Research Institute of Influenza, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Clinical and Diagnostic Center, Research Institute of Influenza, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Lerner, Anna" sort="Lerner, Anna" uniqKey="Lerner A" first="Anna" last="Lerner">Anna Lerner</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Medical Research Center, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research Center, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies against A/H1N1pdm09 influenza viruses in the community as a whole and after infection. We evaluated NI serum antibodies against A/California/07/09(H1N1)pdm and A/South Africa/3626/2013(H1N1)pdm in 134 blood donors of different ages using enzyme-linked lectin assay and in 15 paired sera from convalescents with laboratory confirmed influenza. The neuraminidase (NA) proteins of both A/H1N1pdm09 viruses had minimal genetic divergence, but demonstrated different enzymatic and antigenic properties. 5.2% of individuals had NI antibody titers ≥1:20 against A/South Africa/3626/2013(H1N1)pdm compared to 53% of those who were positive to A/California/07/2009(H1N1)pdm NA. 2% of individuals had detectable NI titers against A/South Africa/3626/13(H1N1)pdm and 47.3% were positive to A/California/07/2009(H1N1)pdm NA among participants negative to hemagglutinin (HA) of A/H1N1pdm09 but positive to seasonal A/H1N1. The lowest NI antibody levels to both A/H1N1pdm09 viruses were detected in individuals born between 1956 and 1968. Our data suggest that NI antibodies against A/South Africa/3626/13 (H1N1)pdm found in the blood donors could have resulted from direct infection with a new antigenic A/H1N1pdm09 variant rather than from cross-reaction as a result of contact with previously circulating seasonal A/H1N1 variants. The immune responses against HA and NA were formed simultaneously right after natural infection with A/H1N1pdm09. NI antibodies correlated with virus-neutralizing antibodies when acquired shortly after influenza infection. A group of middle-aged patients with the lowest level of anti-NA antibodies against A/California/07/2009 (H1N1)pdm was identified, indicating the highest-priority vaccination against A/H1N1pdm09 viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Komissarov, A" uniqKey="Komissarov A">A Komissarov</name></author><author><name sortKey="Fadeev, A" uniqKey="Fadeev A">A Fadeev</name></author><author><name sortKey="Sergeeva, M" uniqKey="Sergeeva M">M Sergeeva</name></author><author><name sortKey="Petrov, S" uniqKey="Petrov S">S Petrov</name></author><author><name sortKey="Sintsova, K" uniqKey="Sintsova K">K Sintsova</name></author><author><name sortKey="Egorova, A" uniqKey="Egorova A">A Egorova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, A" uniqKey="Monto A">A Monto</name></author><author><name sortKey="Kendal, A" uniqKey="Kendal A">A 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